Université Paris - Sud 11 Faculté De Pharmacie
نویسندگان
چکیده
Alzheimer‟s disease (AD) represents the most common form of dementia worldwide, affecting more than 35 million people. Advances in nanotechnology are beginning to exert a significant impact in neurology. These approaches, which are often based on the design and engineering of a plethora of nanoparticulate entities with high specificity for brain capillary endothelial cells, are currently being applied to early AD diagnosis and treatment. In addition, nanoparticles with high affinity for the circulating amyloid-β forms may induce “sink-effect” and improve AD condition. There are also developments in relation to in vitro diagnostics for AD, which includes ultrasensitive nanoparticlebased bio-barcode, immunosensors as well as scanning tunneling microscopy procedures capable of detecting A 1−40 and A 1−42. However, there are concerns regarding the initiation of possible nanoparticle-mediated adverse events in AD, thus demanding the use of precisely assembled nanoconstructs from biocompatible materials. Key advances and safety issues are reviewed and discussed.
منابع مشابه
Hepatocellular Carcinoma: Epidemiology and Etiology
Davide Degli Esposti1,2, Morando Soffritti3,*, Antoinette Lemoine1,2, Eva Tibaldi3 and Marco Manservigi3 1AP-HP, Hôpital Paul Brousse, Service de Biochimie et Biologie Moléculaire, Inserm; Université Paris-Sud 11; PRES Universud-Paris; Paul Vaillant Couturier 2Laboratoire de Biochimie et Biologie Cellulaire, Faculté de Pharmacie, Université Paris-Sud 11, Jean Baptiste Clément 3Cesare Maltoni Ca...
متن کاملShort Communication Threshold to N-methyl-D-aspartate-induced seizures in mice undergoing chronic nutritional magnesium deprivation is lowered in a way partly responsive to acute magnesium and antioxidant administrations
Pierre Maurois†, Nicole Pages†, Pierre Bac, Michèle German-Fattal, Geneviève Agnani, Bernadette Delplanque, Jean Durlach, Jacques Poupaert and Joseph Vamecq* Faculté de Pharmacie, Université Paris Sud 11, F-92296 Châtenay-Malabry, France CNRS UMR 8162, IFR 13, Centre Chirurgical Marie Lannelongue, F-92350 Le Plessis Robinson, France Laboratoire de Toxicologie, Faculté de Pharmacie, Université L...
متن کاملHEMATOPOIESIS AND STEM CELLS Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice
1Inserm Unité Mixte de Recherche (UMR) S996, Université Paris-Sud, Laboratory of Excellence in Research on Medication and Innovative Therapeutics, Clamart, France; 2Inserm U819, Paris, France; 3Laboratoire de Pathogénie Virale, Institut Pasteur, Paris, France; 4Plateforme d’Immunomonitorage, Institut Paris-Sud d’Innovation Thérapeutique, Clamart, France; 5Laboratoire d’Hématologie, Assistance P...
متن کاملVan-der-Waals based Solvates of C60 with CBr2Cl2 and CBr2(CH3)2
Departament de Física, ETSEIB, Universitat Politècnica de Catalunya, Diagonal 647, 08028 Barcelona, Catalonia, Spain 2 LETIAM, EA7357, IUT Orsay, Université Paris Sud, rue Noetzlin, 91405 Orsay Cedex, France 3 Institut Laue Langevin, 71 avenue des Martyrs CS 20156 38042 GRENOBLE CEDEX 9, France 4 Laboratoire de Chimie Physique, CAMMAT, Faculté de Pharmacie, Université Paris Descartes, 4 avenue ...
متن کاملLocalization of the Clostridium difficile cysteine protease Cwp 84 and insights 1 into its maturation process
2 Service de Microbiologie, Hôpital Jean Verdier, Assistance Publique-Hôpitaux de Paris, 8 France 9 10 11 Running title: Localization and maturation process of Cwp84 of Clostridium difficile 12 13 * Corresponding author: 14 Claire Janoir 15 Université Paris-Sud 11, Faculté de Pharmacie, Département de Microbiologie, 16 5 rue Jean Baptiste Clément, 92296 Châtenay-Malabry Cedex, France. 17 Phone:...
متن کامل